CHO-HER2 Cells

Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The CHO-HER2-High cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the HER2 receptor at a high level, approximately 85,000 molecules per cell. This cell line was generated using an innovative landing pad technology that ensures the HER2 gene is integrated at a specific, pre-validated genomic locus, allowing for consistent and reliable expression. HER2, also known as ERBB2 or CD340, is a member of the epidermal growth factor receptor (EGFR) family and plays a crucial role in regulating cell growth and differentiation. It is well-known for its involvement in breast and ovarian cancers, where its overexpression is linked to increased tumor aggressiveness and poorer patient outcomes. HER2 is a key target for cancer therapies such as Trastuzumab (Herceptin) and Pertuzumab (Perjeta). This cell line is versatile, supporting both adherent and suspension culture conditions, with adherent cells exhibiting an epithelial-like morphology. The expression of CXCR7 in this cell line was confirmed using flow cytometry.